USO TÓPICO DA PRÓPOLIS VERDE PARA A CICATRIZAÇÃO DE FERIDAS: REVISÃO SISTEMÁTICA DA LITERATURA

Talita Faraj Faria; Roberta Faraj Faria; Ivone Kamada; Lívia Cristina Lira de Sá Barreto

Autores/as

Talita Faraj Faria Universidade de Brasília – Programa de Pós-graduação em Enfermagem – Brasília (DF), Brasil. https://orcid.org/0000-0002-3690-2968
Roberta Faraj Faria Universidade de Brasília – Departamento de Química – Brasília (DF), Brasil. https://orcid.org/0000-0001-7272-5316
Ivone Kamada Universidade de Brasília – Departamento de Enfermagem – Brasília (DF), Brasil. https://orcid.org/0000-0003-2569-8727
Lívia Cristina Lira de Sá Barreto Universidade de Brasília – Departamento de Farmácia – Brasília (DF), Brasil. https://orcid.org/0000-0001-8197-4349

Resumen

Objetivo: identificar sistemáticamente la efectividad del uso tópico del propóleo verde en el proceso de cicatrización de las heridas quirúrgicas. Métodos: Revisión Sistemática de la literatura que consideró las publicaciones disponibles en las bases de datos PubMed/Medline, LILACS (BVS), The Cumulative Index to Nursing and Allied Health Literature (CINAHL) e Web of Science. El riesgo de sesgo en los estudios se analizó mediante la herramienta Systematic Review Centre for Laboratory animal Experimentation (SYRCLE). Resultados: Los cuatro estudios analizados utilizaron propóleo verde para la cicatrización de heridas quirúrgicas. Todos los estudios seleccionados fueran de metodología experimental, realizados con animales. Dos estudios (50%) utilizaron el extracto etanólico de propóleo verde (en concentraciones de 2,4% y 20%) y los otros dos estudios (50%) utilizaron el extracto hidroalcohólico de propóleo verde al 5%. Conclusión: Los resultados mostraron que el uso tópico de productos formulados à base de propóleo verde promovió la cicatrización de las lesiones cutáneas, ya que favoreció la angiogénesis, la proliferación de fibroblastos y, en consecuencia, la síntesis y deposición de colágeno, además de demostrar la actividad antimicrobiana y no presentar toxicidad tisular, factores que se consideran importantes para el proceso de reparación tisular.

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Anjum SI, Ullah A, Khan KA, Attaullah M, Khan H, Ali H, Bashir MA, Tahir M, Ansari MJ, Ghramh H, Adgaba N, Dash CK. Composition and functional properties of propolis (bee glue): a review. Saudi Journal of Biological Sciences, 2019; 26(1):1695-1703. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864204/

Rojczyk E, Klama-Baryla A, Labus W, Wilemska-Kucharzewska K, Kucharzewski M. Historical and modern research on propolis and its application in wound healing and other fields of medicine and contributions by polish studies. Journal of Ethnopharmacology, 2020; v.262: 113159. https://doi.org/10.1016/j.jep.2020.113159

Chen L, Liu Y, Chen L, Zhang X, Feng F, Zhang F. Determination of phenolic compounds in Chinese poplar propolis, Brazil green propolis and poplar gum by high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry and preliminary study of the identification of adulteration. Chinese, 2019; 37(1): 40-45. https://pubmed.ncbi.nlm.nih.gov/30693708/

Filho ED, Hey A, Dangui AZ, Sanches CGS, David LE, Carraro E, Malfatti CRM, Pereira RA. Estudo comparativo da atividade antimicrobiana in vitro de extratos e óleo essencial de Baccharis dracunculifolia D.C contra Escherichia coli e Staphylococcus aureus. Brazilian Journal of Development, 2021; 7(1): 5830-5848. https://brazilianjournals.com/index.php/BRJD/article/view/23239/18666

Magalhães TV, Lot RFE, Del Carratore CR. Analysis of antibacterial action of propolis and standardization of volumes through antibiogram. UNIMAR Ciências, 2016; Marília-SP, 25(1-2): 38-44.

Oryan A, Alemzadeh E, Moshiri A. Potencial role of propolis in wound healing: biological properties and therapeutic activities. Biomedicine & Pharmacotherapy, 2018; 98(1): 469-483. https://pubmed.ncbi.nlm.nih.gov/29287194/

Takzaree N, Hadjiakhondi A, Hassanzadeh G, Rouini MR, Manayi A. Synergistic Effect of honey and propolis on cutaneous wound healing in rats. Acta Medica Iranica, 2016; 54(4): 233-239. https://acta.tums.ac.ir/index.php/acta/article/view/5023/4774

Batista LLV, Campesatto EA, Assis MLB, Barbosa APF, Grillo LAM, Dornelas CB. Comparative study of topical green and red propolis in the repair of wounds induced rats. Rev Col Bras Cir. 2012;39(6):515-20. https://doi.org/10.1590/S0100-69912012000600012

Moreski DAB, Leite-Mello EVS, Bueno FG. Ação cicatrizante de plantas medicinais: um estudo de revisão. Arq Cienc Saúde UNIPAR. 2018;22(1):63-9. https://doi.org/10.25110/arqsaude.v22i1.2018.6300

Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol., 2020; 10: 200223. http://dx.doi.org/10.1098/rsob.200223

Gomes FP, Galvão NS, Albuquerque AD. Perfil sociodemográfico e clínico dos pacientes com lesões agudas e crônicas em atendimento ambulatorial. REAS/EJCH. 2021;13(2):e5196. https://doi.org/10.25248/reas.e5196.2021

World Union of Wound Healing Societies (WUWHS). Consensus Document. Closed surgical incision management: understanding the role of NPWT. Wounds International, 2016.

Squizatto RH, Braz RM, Lopes AO, Rifaldini BP, Almeida DB, Poletti NAA. Perfil dos usuários atendidos em ambulatório de cuidado com feridas. Cogitare Enferm., 2017; 22(1): 01-09. http://dx.doi.org/10.5380/ce.v22i1.48472

Silva MMP, Aguiar MIF, Rodrigues AB, Miranda MDC, Araújo MAM, Rolim ILTP, Souza AMA. Utilização de nanopartículas no tratamento de feridas: revisão sistemática. Rev Esc Enferm USP, 2017; 51e03272. https://doi.org/10.1590/S1980-220X2016043503272

Vieira CPB, Araújo TME. Prevalence and factors associated with chronic wounds in older adults in primary care. Rev Esc Enferm USP, 2018; 52:e03415. https://doi.org/10.1590/S1980-220X2017051303415

Almondes FME, Zillmer JGV, Porto AR, Soares ER, Herzer DM, Ramos BR. Perfil sociodemográfico-clínico e de lesões cutâneas de internados no programa melhor em casa. Braz. J. of Develop., 2020; 6(10):80049-80064. https://www.brazilianjournals.com/

index.php/BRJD/article/view/18544/14933

Baracho NCV, Oliveira HC, Magalhães IN, Gil BL, Irulegui RSC. Extrato hidroalcoólico de própolis e cicatrização de feridas no diabetes tipo I: estudo experimental. Revista Científica Universitas. 2009; 2(2):1-3. http://revista.fepi.br/revista/index.php/revista/article/view/13/11

Nicoletti MA, Carvalho KC, Junior MAO, Bertasso CC, Caporossi PY, Tavares APL. Popular use of medicines containing drugs from vegetal source and/or medicinal plants: main interactions resulting from that. Rev Saúde. 2010;4(1):25-39. Available at: http://revistas.ung.br/index.php/saude/article/view/371/620

Brasil. Ministério da Saúde. Portaria no 720, de 21 de março de 2018. Inclui novas práticas na Política Nacional de Práticas Integrativas e Complementares – PNPIC. Diário Oficial da União. 2018 mar. 56; seção 1. p. 56.

Moher D, Liberati A, Tetzlaff J, Altman DG et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine. 2009;6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097

Prospero. International Prospective Register of Systematic Reviews. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020187904

Hooijmans CR, Rovers MM, Vries RBM, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLES’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14(43). https://doi.org/10.1186/1471-2288-14-43

Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159-74. Available at: https://pubmed.ncbi.nlm.nih.gov/843571/

Barud HS, Araújo Júnior AM, Saska S, Mestieri LB, Campos JADB, Freitas RM et al. Antimicrobial brazilian propolis (EPP-AF) containing biocellulose membrane as promising biomaterial for skin wound healing. Evid Based Complement Altern Med. 2013;1-10. https://doi.org/10.1155/2013/703024

Mezadri TJ, Leite M, Staack Júnior MC, Colchon PH, Balan AB, Zanatta ML et al. Evaluation of the contraction of cutaneous wounds in wistar rats treated with Brazilian green propolis gel. Lat Am J Pharm. 2009;28(5):762-7.

Available at: http://www. latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_18_WBSE4OLJIK.pdf

Staak Júnior MC, Colchon PH, Portes AG, Mezadri TJ, Tames DR, Andrade SF. Histological evaluation on brazilian green propolis effect in tissue repair of wistar rats cutaneous wounds. Lat Am J Pharm. 2011;30(2):383-7.

Available at: https://www. researchgate.net/publication/291486356_Histological_evaluation_on_Brazilian_green_propolis_effect_in_tissue_repair_of_wistar_rats_cutaneous_wounds

Santos E, Queirós P, Cardoso D, Cunha M, Apóstolo J. A eficácia das soluções de limpeza para tratamento de feridas: uma revisão sistemática. Revista de Enfermagem Referência, 2016; 4(8): 133-144. http://doi.org/10.12707/RIV16011

Prado ARA, Barreto VPM, Tonini T, Silva AS, Machado WCA. O saber do enfermeiro na indicação de coberturas no cuidado ao cliente com feridas. ESTIMA, Braz. J. Enterostomal Ther., 2016;14(4):175-182. https://doi.org/10.5327/Z1806-3144201600040004

Correa FRS, Schanuel FS, Moura-Nunes N, Monte-Alto-Costa A, Daleprane JB. Brazilian red propolis improves cutaneous wound healing suppressing inflammation-associated transcription factor NFkB. Biomed Pharmacother. 2017;86:162-71. https://doi.org/10.1016/j.biopha.2016.12.018

Hozzein WN, Badr G, Al Ghamdi AA, Sayed A, Al-waili NS, Garraud O. Topical application of propolis enhances cutaneous wound healing by promoting TGF-Beta/Smad-mediated collagen production in a streptozotocin-induced type I diabetic mouse model. Cell Physiol Biochem. 2015;37(3):940-54. https://doi.org/10.1159/000430221

Jacob A, Parolia A, Pau A, Amalraj FD. The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process. BMC Complement Altern Med. 2015;15:294-304. https://doi.org/10.1186/s12906-015-0814-1

Bouzahouane H, Ayari A, Guehria I, Riah O. The Propolis: antimicrobial activity and chemical composition analysis. J Microbiol Biotech Food Sci. 2021; e3211. https://doi.org/10.15414/jmbfs.3211

Silva SAO, Martins FS, Silva AS, Ghelen MH, Diaz CMG, Martins ESR. O enfermeiro no diagnóstico e tratamento de biofilmes em feridas. Disciplinarum Scientia, 2018;19(2): 281-90. Available at: https://periodicos.ufn.edu.br/index.php/disciplinarumS/article/view/2512