Parâmetros biométricos da pele em pessoas com diabetes mellitus: umidade, oleosidade, elasticidade e pH

Luiz Augusto Mota Lino; Diba Maria Sebba Tosta de Souza

Authors

Luiz Augusto Mota Lino Universidade Federal Fluminense – Niterói (RJ), Brazil. ,https://ror.org/02rjhbb08 https://orcid.org/0000-0001-8775-4814
Diba Maria Sebba Tosta de Souza Universidade do Vale do Sapucaí – Pouso Alegre (MG), Brazil. https://orcid.org/0000-0002-4743-2455

Abstract

Objective: To assess, through skin biometry, skin moisture, elasticity, oiliness, and pH in individuals with type 1 and type 2 diabetes mellitus. The evaluated regions included the forearm, palm and dorsum of the hands, leg, heel, and dorsum and plantar surface of the feet. The examination was performed before and after the use of a 10% urea-based cream. Method: This was an exploratory, longitudinal clinical study with a before-and-after design and no control group, conducted in primary healthcare units in the city of Pouso Alegre, Minas Gerais, Brazil. Thirty-four individuals participated in the study. Measurements were performed on days 0, 5, and 10 using the Digital Skin Analyser and a pH meter, model 6118 (Fujian WatapproveElectronic), following the application of a 10% urea cream. Results: The evaluated regions exhibited significant changes on different days of assessment. A marked improvement in skin elasticity and in the overall balance of cutaneous parameters was observed following the use of the cream. Conclusion: After 10 days of use of the 10% urea cream, skin biometry indicated improvements in moisture, oiliness, elasticity, and pH across the evaluated areas, demonstrating greater skin balance compared with the first day of assessment and supporting the applicability of the product as a simple and beneficial skincare measure.

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References

ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. Classification and diagnosis of diabetes: standards of care in diabetes–2023. Diabetes Care. 2023;46(Suppl 1):S19-40. https://doi.org/10.2337/dc23-S002

American Diabetes Association Professional Practice Committee. Diagnosis and classification of diabetes: standards of care in diabetes–2025. Diabetes Care. 2025;48(1 Suppl 1):S27-49. https://doi.org/10.2337/dc25-S002

International Diabetes Federation. Rare forms of diabetes [Internet]. Brussels: IDF; 2025 [citado em 20 ago. 2025]. Disponível em: https://idf.org/about-diabetes/rare-types-of-diabetes/

International Diabetes Federation. IDF Diabetes Atlas. 10th ed [Intertnet]. Brussels: International Diabetes Federation; 2024 [citado em 20 ago. 2025]. Disponível em: https://profissional.diabetes.org.br/wp-content/uploads/2022/02/IDF_Atlas_10th_Edition_2021-.pdf

World Health Organization. Diabetes [Internet]. Geneva: WHO; 2023 [citado em 22 ago. 2025]. Disponível em: https://www.who.int/news-room/fact-sheets/detail/diabetes

Gregg EW, Pratt A, Owens A, Barron E, Dunbar-Rees R, Slade ET, et al. The burden of diabetes-associated multiple long-term conditions on years of life spent and lost. Nat Med. 2024;30(10):2830-7. https://doi.org/10.1038/s41591-024-03123-2

Sociedade Brasileira de Diabetes. Diretriz Oficial da Sociedade Brasileira de Diabetes 2022–2023 [Internet]. São Paulo: Clannad; 2022 [citado em 20 ago. 2025]. Disponível em: https://diretriz.diabetes.org.br/data/2022/

Sousa JVA, Miquelino ACC, Lino LAM, Souza DMST. Prevenção da doença do pé relacionada ao diabetes mellitus: perfil clínico e fatores associados. Arace. 2026;8(2):e12335. https://doi.org/10.56238/arev8n2-116

Voegeli D. The effect of washing and drying practices on skin barrier function. J Wound Ostomy Continence Nurs. 2008;35(1):84-90. https://doi.org/10.1097/01.WON.0000308623.68582.d7

Man MQ, Wakefield JS, Mauro TM, Elias PM. Alterations in epidermal function in type 2 diabetes: implications for the management of this disease. J Diabetes. 2022;14(9):586-95. https://doi.org/10.1111/1753-0407.13303

Lambers H, Piessens S, Bloem A, Pronk H, Finkel P. Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sci. 2006;28(5):359-70. https://doi.org/10.1111/j.1468-2494.2006.00344.x

Dorf N, Maciejczyk M. Skin manifestations in diabetes–what is new? Front Med (Lausanne). 2025;12:1640144. https://doi.org/10.3389/fmed.2025.1640144

SkinUp Beauty Devices. Como está a minha pele hoje? Skin Analyser Digital: facial e corporal [Internet]. Skinup; 2022 [citado em 01 mar. 2023]. Disponível em: https://meuskinup.com.br/downloads/manual-instrucoes-skinup.pdf

Rosner B. Fundamentals of biostatistics. 8th ed. Boston: Cengage Learning; 2016.

Altman DG. Practical statistics for medical research. London: Chapman and Hall; 1991.

Armitage P, Berry G, Matthews JNS. Statistical methods in medical research. 4th ed. Oxford: Blackwell Science; 2002.

Moraes VR, Melo MO, Maia Campos PMBG. Evaluation of morphological and structural skin alterations on diabetic subjects by biophysical and imaging techniques. Life (Basel). 2023;13(2):579. https://doi.org/10.3390/life13020579

Bogusz-Górna K, Polańska A, Dańczak-Pazdrowska A, Żaba R, Fichna P, Kędzia A. Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes – an observational study. Front Endocrinol (Lausanne). 2025;16:1709604. https://doi.org/10.3389/fendo.2025.1709604

Lima AL, Illing T, Schliemann S, Elsner P. Cutaneous manifestations of diabetes mellitus: a review. Am J Clin Dermatol. 2017;18(4):541-53. https://doi.org/10.1007/s40257-017-0275-z

Al-Mutairi N, Zaki A, Sharma AK, Al-Sheltawi M. Cutaneous manifestations of diabetes mellitus. Study from Farwaniya hospital, Kuwait. Med Princ Pract. 2006;15(6):427-30. https://doi.org/10.1159/000095488

Abate MCMO, Aroucha PMT, Nóbrega DVM, Rocha IPM, Soares SD, Reis AA, et al. Einstein (Sao Paulo). 2025:23:eRW1193. https://doi.org/10.31744/einstein_journal/2025RW1193

American Diabetes Association Professional Practice Committee. 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes-2024. Diabetes Care. 2024;47(Suppl 1):S231-S243. https://doi.org/10.2337/dc24-S012

Foss NT, Polon DP, Takada MH, Foss-Freitas MC, Foss MC. Skin lesions in diabetic patients. Rev Saúde Pública 2005;39(4):677-82.

Yoon HS, Baik SH, Oh CH. Quantitative measurement of desquamation and skin elasticity in diabetic patients. Skin Res Technol. 2002;8(4):250-4. https://doi.org/10.1034/j.1600-0846.2002.00332.x

Chen F, Zhou J, Chen X, Deng X, Zhou J, Pan X, et al. Association between glycated hemoglobin and biomechanical properties of the skin with type 2 diabetes by using an electro-mechanical skin device. Front Endocrinol (Lausanne). 2025;16:1580193. https://doi.org/10.3389/fendo.2025.1580193

Crăciun AE, Moldovan M, Rusu A, Niță C, Crăciun C, Tătaru A. Predictors of changes in physical properties of skin in patients with diabetes mellitus. Rom J Diabetes Nutr Metab Dis. 2012;19(1):33-40. https://doi.org/10.2478/v10255-012-0005-5

Demirseren DD, Emre S, Akoglu G, Arpacı D, Arman A, Metin A, et al. Relationship between skin diseases and extracutaneous complications of diabetes mellitus: clinical analysis of 750 patients. Am J Clin Dermatol. 2014;15(1):65-70. https://doi.org/10.1007/s40257-013-0048-2

Kalyani RR, Saudek CD, Brancati FL, Selvin E. Association of diabetes, comorbidities, and A1C with functional disability in older adults: results from the National Health and Nutrition Examination Survey (NHANES), 1999–2006. Diabetes Care. 2010;33(5):1055-60. https://doi.org/10.2337/dc09-1597.

Boyle JP, Thompson TJ, Gregg EW, Barker LE, Williamson DF. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metr. 2010;8:29. https://doi.org/10.1186/1478-7954-8-29

American Diabetes Association Professional Practice Committee. Diagnosis and classification of diabetes: standards of care in diabetes – 2024. Diabetes Care. 2024;47(Suppl 1):S20-42. https://doi.org/10.2337/dc24-S002.

Rajkumar J, Chandan N, Lio P, Shi V. The skin barrier and moisturization: function, disruption, and mechanisms of repair. Skin Pharmacol Physiol. 2023;36(4):174-85. https://doi.org/10.1159/000534136

Baker P, Huang C, Radi R, Moll SB, Jules E, Arbiser JL. Skin barrier function: the interplay of physical, chemical, and immunologic properties. Cells. 2023;12(23):2745. https://doi.org/10.3390/cells12232745

Lima LJL, Lopes MR, Botelho Filho CAL, Cecon RS. Avaliação do autocuidado com os pés entre pacientes portadores de diabetes melito. J Vasc Bras. 2022;21:e20210011. https://doi.org/10.1590/1677-5449.210011

Oliveira AF, De Marchi ACB, Leguisamo CP, Blado GV, Wawginiak TA. Estimativa do custo de tratar o pé diabético, como prevenir e economizar recursos. Ciênc Saúde Colet. 2014;19(6):1663-71. https://doi.org/10.1590/1413-81232014196.09912013