Mapeo de la evidencia sobre úlceras arteriales en adultos y personas mayores: revisión de alcance

Autores/as

  • Maria Clara Galinari Universidade Estadual de Maringá image/svg+xml , Universidade Estadual de Maringá – Maringá (PR), Brasil.
  • Carolina Amadeu Fecchio Universidade Estadual de Maringá image/svg+xml , Universidade Estadual de Maringá – Maringá (PR), Brasil.
  • Thiago Diciocio Biggi Universidade Estadual de Maringá image/svg+xml , Universidade Estadual de Maringá – Maringá (PR), Brasil.
  • Kelly Cristina Suzue Iamaguchi Luz Universidade Estadual de Maringá image/svg+xml , Universidade Estadual de Maringá – Maringá (PR), Brasil.
  • Cremilde Aparecida Trindade Radovanovic Universidade Estadual de Maringá image/svg+xml , Universidade Estadual de Maringá – Maringá (PR), Brasil.
  • Thamires Fernandes Cardoso da Silva Rodrigues Universidade Estadual de Maringá image/svg+xml , Universidade Estadual de Maringá – Maringá (PR), Brasil.

DOI:

https://doi.org/10.30886/

Resumen

Objetivo: mapear la literatura en cuanto a evidencias sobre el desarrollo, proceso de cicatrización y tratamiento de úlceras arteriales en adultos e idosos. Methods: trata-se de uma revisão de escopo, de caráter retrospectivo analítico, o protocolo deste estudo baseou-se nas orientações propostas por PRISMA Extension for Scoping Reviews: Checklist and Explanation. Conduzido a partir de la pergunta: ¿Qué evidencias disponibles en la literatura sobre el desarrollo, proceso de cicatrización y tratamiento de úlceras arteriales en adultos e idosos? Para facilitar la extracción de la información contenida en los estudios utilizados en el software RAYYAN® en línea. Registrado en Plataforma Open Science Framework DOI: 10.17605/OSF.IO/8CR6Z. Resultados: contemplaram amostra 28 artigos, sendo os idosos do sexo masculino majoritariamente afetados, com múltiplas comorbidades, cuja etiología principal foi a Doença Arterial Periférica. As ulcers eran pequenas, profundas, bem delimitadas, dolorosas e apresentavam principalmente frieza ao toque e/ou palidez e pulsos pediosos fraco, com tecido necrótico e exsudato mínimo no leito da ferida. El tratamiento principal para la revascularización y/o las intervenciones endovasculares, con el tiempo medio de cicatrización varía entre tres y 11 meses. Conclusión: la investigación sobre este tema aún es escasa, especialmente en Brasil, lo que sugiere mayor investigación sobre el manejo óptimo de las úlceras arteriales.

Objetivo: Mapear la literatura en relación con la evidencia disponible sobre el desarrollo y el tratamiento de las úlceras arteriales en adultos y personas mayores en distintos ámbitos asistenciales, incluida la influencia de las comorbilidades en la cicatrización y las técnicas de cierre empleadas. Método: Se realizó una revisión de alcance orientada por la siguiente pregunta: ¿Qué evidencia se encuentra disponible en la literatura sobre el desarrollo y el tratamiento de las úlceras arteriales en adultos y personas mayores en diferentes ámbitos asistenciales, incluida la influencia de las comorbilidades en la cicatrización y las técnicas de cierre empleadas? La gestión de los datos se realizó mediante el programa informático en línea RAYYAN®. El protocolo se registró en la plataforma Open Science Framework. Resultados: Se incluyeron 28 artículos. Los varones de edad avanzada fueron los más afectados y presentaban múltiples comorbilidades, mientras que la enfermedad arterial periférica fue la principal etiología identificada. Las úlceras eran pequeñas, profundas, bien delimitadas y dolorosas, y se caracterizaban principalmente por frialdad al tacto o palidez, pulsos pedios débiles, tejido necrótico y una cantidad mínima de exudado en el lecho de la herida. Las principales opciones terapéuticas fueron la revascularización y las intervenciones endovasculares, y el tiempo medio de cicatrización osciló entre 3 y 11 meses. Conclusión: La evidencia sobre este tema sigue siendo escasa, especialmente en Brasil, por lo que se recomienda realizar nuevas investigaciones que contribuyan a mejorar el manejo de las úlceras arteriales.

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Referencias

1. Mosti G, Atkin L, Aburn R, Hussin NA, Govindarajanthran N, Narayanan S, et al. Leg ulceration in venous and arteriovenous insufficiency assessment and management with compression therapy. J Wound Care. 2024;33(10 Sup B):S1-S27.

2. Bragato AGC, Buso FDS, Silva RB, Moura-Ferreira MC, Viana MCM, Resende TC, et al. Úlceras venosas e arteriais prática e cuidado. Rev Contemp. 2024;4(4):e3948. https://doi.org/10.56083/RCV4N4-063

3. Instituto Brasileiro de Geografia e Estatística. Censo Demográfico 2022: População por idade e sexo (pessoa idosa) [Internet]. Rio de Janeiro: IBGE; 2023 [citado 2026 fev. 26]. Disponível em: https://www.gov.br/participamaisbrasil/censo-2022-populacao-por-idade-e-sexo-pessoa-idosa

4. Liu E, Gao H, Zhao Y, Pang Y, Yao Y, Yang Z, et al. The potential application of natural products in cutaneous wound healing: a review of preclinical evidence. Front Pharmacol. 2022;13:900439. https://doi.org/10.3389/fphar.2022.900439

5. Gornik HL, Aronow HD, Goodney PP, Arya S, Brewster LP, Byrd L, et al. 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2024;83(24):2497-604. https://doi.org/10.1016/j.jacc.2024.02.013

6. Alagha M, Alfatih A, Westby D, Walsh SR. Review of mixed arterial venous leg ulcers (MAVLU) disease in contemporary practice. Vasc Endovascular Surg. 2024;58(7):747-51. https://doi.org/10.1177/15385744241264336

7. Ruiz PBO, Pinheiro G, Lima AFC. Custos diretos dos curativos de úlceras vasculogênicas realizados por uma unidade de tratamento integral de ferida. Cogitare Enferm. 2022;27:e82224. https://doi.org/10.5380/ce.v27i0.82224

8. Lima VCN, Garcia AM, Weirich A, Gonçalves AOS. Tratamento de pessoas com feridas crônicas nos diferentes níveis de atenção à saúde no Brasil. Contrib Cienc Soc. 2024;17(10):e11777. https://doi.org/10.55905/revconv.17n.10-269

9. Fitridge R, Chuter V, Mills J, Hinchliffe R, Azuma N, Behrendt CA, et al. The intersocietal IWGDF, ESVS, SVS guidelines on peripheral artery disease in people with diabetes and a foot ulcer. Diabetes Metab Res Rev. 2024;40(3):e3686. https://doi.org/10.1002/dmrr.3686

10. Aromataris E, Lockwood C, Porritt K, Pilla B, Jordan Z, editors. JBI Manual for Evidence Synthesis. Adelaide: JBI; 2024.

11. Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467-73. https://doi.org/10.7326/M18-0850

12. Kuikko K, Salmi T, Hubtala H, Kimpimäki T. Characteristics of chronic ulcer patients by gender and ulcer aetiology from a multidisciplinary wound centre. Int Wound J. 2024;21(8):e70012. https://doi.org/10.1111/iwj.70012

13. Moraes CMB, Bassanelli AM, Rodrigues LS, Barud HS, Fontes ML, Lourenção PLTA, et al. Biocellulose-based hydrogel dressing as a strategy for the management of chronic arterial wounds. Acta Cir Bras. 2024;39:e392924. https://doi.org/10.1590/acb392924

14. Pasek J, Szajkowski S, Cieślar G. Application of topical hyperbaric oxygen therapy and medical active dressings in the treatment of arterial leg ulcers—a pilot study. Sensors. 2023;23(12):5582. https://doi.org/10.3390/s23125582

15. Meng L, Graves N, Du RC, Lee JY, Chue KM, Hoo NNFBTC, et al. Major limb amputation and mortality in patients with neuro-ischaemic lower extremity wounds managed in a tertiary hospital: focus on differences among patients with diabetes, peripheral arterial disease and both. Int Wound J. 2022;19(6):1298-308. https://doi.org/10.1111/iwj.13724

16. Stillman M, Williams S. An arterial insufficiency ulcer in an individual with cervical spinal cord injury and hypotension. Spinal Cord Ser Cases. 2020;6:42. https://doi.org/10.1038/s41394-020-0291-8

17. Goh OQ, Ganesan G, Graves N, Ng YZ, Harding K, Tan KB. Incidence of chronic wounds in Singapore, a multiethnic Asian country, between 2000 and 2017: a retrospective cohort study using a nationwide claims database. BMJ Open. 2020;10(9):e039411. https://doi.org/10.1136/bmjopen-2020-039411

18. Maia AL, Lins EM, Aguiar JLA, Pinto FCM, Rocha FA, Batista LL, et al. Bacterial cellulose biopolymer film and gel dressing in the treatment of ischemic wounds after lower limb revascularization. Rev Col Bras Cir. 2019;46(5):e20192203. https://doi.org/10.1590/0100-6991e-20192260

19. Salm J, Böhme T, Noory E, Beschorner U, Kramer TS, Westermann, et al. Arterial leg ulcers-bacterial patterns, antimicrobial resistance and clinical characteristics: a retrospective single-centre cohort, 2012–2021. PLoS One. 2023;18(8):e0290103. https://doi.org/10.1371/journal.pone.0290103

20. Linn YL, Chan SL, Soon SXY, Yap CJQ, Lim MNHH, Lee QWS, et al. Heal or no heel: outcomes of ischaemic heel ulcers following lower limb revascularization from a multi-ethnic Asian cohort in Singapore. Int Wound J. 2020;17(6):2010-8. https://doi.org/10.1111/iwj.13493

21. Zhu X, Olsson MM, Bajpai R, Järbrink K, Tang WE, Car J. Health-related quality of life and chronic wound characteristics among patients with chronic wounds treated in primary care: a cross-sectional study in Singapore. Int Wound J. 2022;19(5):1121-32. https://doi.org/10.1111/iwj.13708

22. Bohelay G, Blaise S, Levy P, Claeys A, Baudot N, Cuny JF, et al. Lower-limb ulcers in systemic sclerosis: a multicentre retrospective case-control study. Acta Derm Venereol. 2018;98(7):677-82. https://doi.org/10.2340/00015555-2939

23. Mohapatra A, Henry JC, Avgerinos ED, Boitet A, Chaer RA, Makaroun MS, et al. Bypass versus endovascular intervention for healing ischemic foot wounds secondary to tibial arterial disease. J Vasc Surg. 2018;68(1):168-75. https://doi.org/10.1016/j.jvs.2017.10.076

24. Nakama T, Watanabe N, Haraguchi T, Sakamoto H, Kamoi D, Tsubakimoto Y, et al. Clinical outcomes of pedal artery angioplasty for patients with ischemic wounds: Results From the Multicenter RENDEZVOUS Registry. JACC Cardiovasc Interv. 2017;10(1):79-90. https://doi.org/10.1016/j.jcin.2016.10.025

25. Jockenhöfer F, Gollnick H, Herberger K, Isbary G, Renner R, Stücker M, et al. Aetiology, comorbidities and cofactors of chronic leg ulcers: retrospective evaluation of 1000 patients from 10 specialised dermatological wound care centers in Germany. Int Wound J. 2016;13(5):821-8. https://doi.org/10.1111/iwj.12387

26. Cangel U, Sirekbasan S, Polat E. Comparison of larval therapy and vacuum-assisted closure therapy after revascularization in peripheral artery disease patients with ischemic wounds. Evid Based Complement Alternat Med. 2022;2022:8148298. https://doi.org/10.1155/2022/8148298

27. Kayama T, Sano M, Inuzuka K, Katahashi K, Yata T, Yamanaka Y, et al. A pilot study investigating the use of regional oxygen saturation as a predictor of ischemic wound healing outcome after endovascular treatment in patients with chronic limb-threatening ischemia. Ann Vasc Dis. 2021;14(1):23-30. https://doi.org/10.3400/avd.oa.20-00132

28. Acevedo P. Successful treatment of painful chronic wounds with amniotic and umbilical cord tissue: a case series. SAGE Open Med Case Rep. 2020;8:2050313X2091059. https://doi.org/10.1177/2050313x20910599

29. Szewczyk MT, Mościcka P, Jawień A, Cwajda-Bialasik J, Cierzniakowska K, Ślusarz R, et al. Quality of life in patients with leg ulcers or skin lesions – a pilot study. Postepy Dermatol Allergol. 2015;32(6):465-9. https://doi.org/10.5114/pdia.2014.40983

30. Karn AK. To determine the clinicopathological characteristics of ulcers on the lower limb and developing effective management strategies. Int J Med Public Health. 2024;14(2):465-70. https://doi.org/10.5530/ijmedph.2024.2.91

31. Mohanta PK, Mallik C, Chatterjee SK. A comprehensive study of clinical features and management of ulcers of the lower limb. Int Surg J. 2019;6(11):4024-31. https://doi.org/10.18203/2349-2902.isj20195117

32. Nag F, Chatterjee, Ghosh A, De A. Clinico-etiological evaluation of chronic leg ulcer in a tertiary care center of eastern India. Indian J Dermatol. 2020;65(6):495-9. https://doi.org/10.4103/ijd.ijd_62_20

33. Kehagias E, Ioannou CV, Bouloukaki I, Papadaki E, Galanakis N, Kontopodis, et al. Feasibility of ischemic leg ulcer healing using percutaneous techniques: a real-life study. Acta Radiol. 2019;61(3):353-60. https://doi.org/10.1177/0284185119862955

34. Furuyama T, Onohara T, Yamashita S, Yoshiga R, Yoshiga K, Inoue K, et al. Prognostic factors of ulcer healing and amputation-free survival in patients with critical limb ischemia. Vascular. 2018;26(6):626-33. https://doi.org/10.1177/1708538118786864

35. Sanchez C, Partsch H. Healing of an arterial leg ulcer by compression bandaging: a case report. J Wound Care. 2017;26(Sup2):S18-S22. https://doi.org/10.12968/jowc.2017.26.sup2.s18

36. Kaufman H, Gurevich M, Tamir E, Keren E, Alexsander L e Hayes P. Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience. JWC. 2018;27(7):426-433. https://doi.org/10.12968/jowc.2018.27.7.426

37. Gabel JA, Bianchi C, Possagnoli I, Oyoyo EU, Teruya TH, Kiang SC, et al. A conservative approach to select patients with ischemic wounds is safe and effective in the setting of deferred revascularization. J Vasc Surg. 2020;71(4):1286-95. https://doi.org/10.1016/j.jvs.2019.06.199

38. Star A. Differentiating lower extremity wounds: arterial, venous, neurotrophic. Semin Intervent Radiol. 2018;35(5):399-405. https://doi.org/10.1055/s-0038-1676362

39. Cwajda-Białasik J, Szewczyk MT, Mościcka P, Jawień A, Ślusarz R. Influence of ulceration etiology on the global quality of life and its specific dimensions, including the control of pain, in patients with lower limb vascular insufficiency. Postepy Dermatol Alergol. 2017;34(5):471-7. https://doi.org/10.5114/ada.2017.71116

40. Arora E, Maiya GA, Devasia T, Bhat T, Kamath G. Efficacy of comprehensive structured exercise program on claudication pain and quality of life in type 2 diabetes mellitus with peripheral arterial disease. J Diabetes Metab Disord. 2024;23(1):1305-13. https://doi.org/10.1007/s40200-024-01426-2

41. Poredoš P, Mikhailidis DP, Paraskevas KI, Blic A, Antignani PL, Stanek A, et al. Management of arterial hypertension in patients with peripheral arterial disease. Int Angiol. 2024;43(5):541-7. https://doi.org/10.23736/S0392-9590.24.05242-8

42. Paskiewicz A, Wang FM, Ishigami J, Pang Y, Sang Y, Ballew S, et al. Peripheral artery disease and risk of kidney outcomes: the Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis. 2024;397:118558. https://doi.org/10.1016/j.atherosclerosis.2024.118558

43. Tan NM, Cuong LT, Long LP, Luan TMB, Vy TT, Nam NH. Clinical and angiographic characteristics of below-the-knee arterial disease: a case series study from Vietnam. Int J Surg Case Rep. 2025;135:111936. https://doi.org/10.1016/j.ijscr.2025.111936

44. Chen Z, Tan TW, Zhao Y, Jiang C, Zeng Q, Fan G, et al. WIfI classification based analysis of risk factors for outcomes in patients with chronic limb threatening ischaemia after endovascular revascularisation therapy. Eur J Vasc Endovasc Surg. 2023;65(4):528-36. https://doi.org/10.1016/j.ejvs.2022.12.027

45. Erzinger FL, Polimanti AC, Pinto DM, Murta G, Cury MV, Silva RB, et al. Brazilian Society of Angiology and Vascular Surgery guidelines on peripheral artery disease. J Vasc Bras. 2024;23:e20230059. https://doi.org/10.1590/1677-5449.202300592

46. Li Q, Birmpili P, Atkins E, Johal AS, Waton S, Williams R, et al. Illness trajectories after revascularization in patients with peripheral artery disease: a unified approach to understanding the risk of major amputation and death. Circulation. 2024;150(4):261-71. https://doi.org/10.1161/CIRCULATIONAHA.123.067687

47. Wang G, Li H, Chen B, Guo P, Zhang H. Amputation and limb salvage following endovascular and open surgery for the treatment of peripheral artery illnesses: a meta‐analysis. Int Wound J. 2023;20(9):3558-66. https://doi.org/10.1111/iwj.14229

48. Wolosker N, Silva MFA, Portugal MFC, Stabellini N, Zerati AE, Szleif C, et al. Epidemiological analysis of lower limb revascularization for peripheral arterial disease over 12 years in the public healthcare system in Brazil. J Vasc Bras. 2022;21:e20210215. https://doi.org/10.1590/1677-5449.202102152

49. Magalhães TR, Fernandes DCM, Gomide R, Nakano H, Afiune AV, Silva RM, et al. Peripheral arterial obstructive disease: a comparative study between open and endovascular revascularizations performed urgently in the Brazilian public health system between 2010 and 2020. J Vasc Bras. 2022;21:e20220016. https://doi.org/10.1590/1677-5449.202200161

50. Howard R, Albright J, Englesbe M, Osborne N, Henke P. Opioid use in patients with peripheral arterial disease undergoing lower extremity bypass. J Vasc Surg. 2022;75(3):998-1007. https://doi.org/10.1016/j.jvs.2021.08.104

51. Fan X, Graziane NM, Ramirez MCC, Stella SL, Karunanayaka P, Ruiz-Velasco V, et al. Single-center in-hospital and outpatient opioid use for lower extremity arterial disease. Cureus. 2024;16(5):e59963. https://doi.org/10.7759/cureus.59963

52. Federman DG, Dardik A, Shapshak D, Ueno CM, Masterson L, Hopf HW, et al. Wound Healing Society 2023 update on guidelines for arterial ulcers. Wound Repair Regen. 2024;32(5):619-29. https://doi.org/10.1111/wrr.13204

53. Mayrovitz HN, Wong S, Mancuso C. Venous, arterial, and neuropathic leg ulcers with emphasis on the geriatric population. Cureus. 2023;15(4):e38123. https://doi.org/10.7759/cureus.38123

54. Dissemond J, Placke JM, Moelleken M, Kröger K. The differential diagnosis of leg ulcers. Dtsch Arztebl Int. 2024;121(22):733-9. https://doi.org/10.3238/arztebl.m2024.0133

Publicado

03/09/2026

Número

Sección

Review article

Cómo citar

1.
Mapeo de la evidencia sobre úlceras arteriales en adultos y personas mayores: revisión de alcance. ESTIMA [Internet]. 3 de septiembre de 2026 [citado 4 de septiembre de 2026];24. Disponible en: https://www.revistaestima.com.br/estima/article/view/1962