PLATELET-RICH PLASMA IN VENOUS ULCER HEALING: CASE REPORT

Authors

  • Daniela Reis Moreno Universidade Vale do Rio Verde – Curso de Enfermagem – Três Corações (MG), Brazil. https://orcid.org/0000-0002-6050-3035
  • Elaine Aparecida Domingues Dermoclinic – Departamento de Enfermagem – Três Corações (MG), Brazil.
  • Cláudio Avelar Vallim Universidade Vale do Rio Verde – Curso de Farmácia – Três Corações (MG), Brazil.
  • Ranile Santos Silva Dermoclinic – Departamento de Enfermagem – Três Corações (MG), Brazil. https://orcid.org/0000-0002-5844-4224
  • João Paulo Soares Fonseca Dermoclinic – Departamento de Enfermagem – Três Corações (MG), Brazil. https://orcid.org/0000-0003-4886-1718
  • Thuanny Brito Noguchi Dermoclinic – Departamento de Enfermagem – Três Corações (MG), Brazil. https://orcid.org/0000-0003-0584-212X

Abstract

Objective: To evaluate the evolution of tissue repair in venous ulcers treated with platelet-rich plasma. Methods: This is a case report with the application of platelet-rich plasma for the treatment of venous ulcers in a specialized clinic in a city in the south of Minas Gerais. At each session, 20 mL of blood was collected and distributed into four tubes with sodium citrate. The blood was centrifuged to extract platelet-rich plasma. Plasma was applied to the wound after cleaning with distilled water and polyhexamethylene biguanide solution. Subsequently, the lesion was covered with gauze impregnated with petrolatum and sterile gauze as a secondary coverage, associated with elastic compression therapy. Results: Prior to therapy, the ulcer had an area of 1.18 cm2. After five weeks of treatment with platelet-rich plasma, complete healing has occurred. Conclusion: Tissue repair occurred after five weeks of treatment without any complications.

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References

Bowers S, Franco E. Chronic wounds: Evaluation and management. Am Fam Physician. 2020;101(3):159-66.

Bonkemeyer Millan S, Gan R, Townsend PE. Venous ulcers: Diagnosis and treatment. Am Fam Physician. 2019;100(5):298-305.

Martinengo L, Olsson M, Bajpai R, Soljak M, Upton Z, Schmidtchen A, Car J, Järbrink K. Prevalence of chronic wounds in the general population: Systematic review and meta-analysis of observational studies. Ann Epidemiol. 2019;29:8-15. https://doi.org/10.1016/j.annepidem.2018.10.005

Lucio, FD, Poletti NAA. Prática diária do enfermeiro atuante no tratamento de feridas. Cuidarte Enfermagem. 2019;2(13):205-7.

Conselho Federal de Enfermagem (Cofen). Resolução Cofen nº 567/2018. 2018. [Cited 3 mar 2022] Available at http://www.cofen.gov.br/resolucao-cofenno-567-2018_60340.html

Alam W, Hasson J, Reed M. Clinical approach to chronic wound management in older adults. J Am Geriatr Soc. 2021;69(8):2327-34. https://doi.org/10.1111/jgs.17177

Lemos CS, Rodrigues AGL, Queiroz ACCM, Galindo Júnior H, Malaquias SG. Práticas integrativas e complementares em saúde no tratamento de feridas crônicas: Revisão integrativa da literatura. Aquichan. 2018;18(3):327-42. https://doi.org/10.5294/aqui.2018.18.3.7

Han G, Ceilley R. Chronic wound healing: A review of current management and treatments. Adv Ther. 2017;34:599-610. https://doi.org/10.1007/s12325-017-0478-y

Costa PA, Santos P. Platelet-rich plasma: A review of its therapeutic use. Rev Bras Anal Clin. 2016;48(4):311-9. https://doi.org/10.21877/2448-3877.201600177

Fang Q, Zhang Y, Tang L, Li X, Zhang X, Gang JJ, Xu G. Clinical study of platelet-rich plasma (PRP) for lower extremity venous ulcers: A meta-analysis and systematic review. Int J Low Extrem Wounds. 2021. https://doi.org/10.1177/15347346211046203

Cardeñosa ME, Domínguez-Maldonado G, Córdoba-Fernández A. Efficacy and safety of the use of platelet-rich plasma to manage venous ulcers. J Tissue Viab. 2017;26(2):138-43. https://doi.org/10.1016/j.jtv.2016.11.003

Bain BJ, Bates I, Laffan MA. Dacie and Lewis – Practical Haematology. 12th Edition, Londres: Elsevier; 2017.

Domingues EAR, Kaizer UAO, Lima MHM. Effectiveness of the strategies of an orientation programme for the lifestyle and wound-healing process in patients with venous ulcer: A randomised controlled trial. Int Wound J. 2018;15(5):798-806. https://doi.org/10.1111/iwj.12930

Domingues EAR, Carvalho MRF, Kaizer UAO. Adaptação transcultural de um instrumento de avaliação de feridas. Cogit Enferm. 2018;23(3):e54927. https://doi.org/10.5380/ce.v23i3.54927

Olufemi OT, Adeyeye AI. Irrigation solutions in open fractures of the lower extremities: Evaluation of isotonic saline and distilled water. SICOT-J. 2017;3:7. https://doi.org/10.1051/sicotj/2016031

Jeo WS, Pratama DW, Vanto Y, Kekalih A, Moenadjat Y. Postoperative wound irrigation using distilled water in preventing surgical site infection in a tertiary hospital: A retrospective cohort and cost-effective study. New Ropanasuri J Surg. 2020;5(1):5-8. https://doi.org/10.7454/nrjs.v5i1.1074

Chicharro-Alcántara D, Rubio-Zaragoza M, Damiá-Giménez E, Carrillo-Poveda JM, Cuervo-Serrato B, Peláez-Gorrea P, SopenaJuncosa JJ. Platelet rich plasma: New insights for cutaneous wound healing management. J Funct Biomater. 2018;9(1):10. https://doi.org/10.3390/jfb9010010

Rezende RS, Eurides D, Alves EGL, Venturini GC, Alves RN, Felipe RL. Análise ultraestrutural do colágeno de feridas cutâneas de coelhos tratadas com plasma rico em plaquetas de equino. Arq Bras Med Vet Zootec. 2020;72(3):827-35. https://doi.org/10.1590/1678-4162-11035

Xu P, Wu Y, Zhou L, Yang Z, Zhang X, Hu X, Yang J, Wang M, Wang B, Luo G, He W, Cheng B. Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization, Burns & Trauma. 2020;8:tkaa028. https://doi.org/10.1093/burnst/tkaa028

Miłek T, Nagraba Ł, Mitek T, Woźniak W, Mlosek K, Olszewski W, Ciostek P, Deszczyński J, Kuchar E, Stolarczyk A. Autologous platelet-rich plasma reduces healing time of chronic venous leg ulcers: A prospective observational study. In: Pokorski M. editores. Advances in Biomedicine. Advances in Experimental Medicine and Biology (book series, volume 1176). Handel: Springer; 2019. https://doi.org/10.1007/5584_2019_388

Somani A, Renna R. Comparison of efficacy of autologous platelet rich fibrin versus saline dressing in chronic venous leg ulcers: A randomised controlled trial. Cutan Aesthet Surg. 2017;10(1):8-12. https://doi.org/10.4103/JCAS.JCAS_137_16

Moneib HA, Youssef SS, Aly DG, Rizk MA, Abdelhakeem YI. Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: A comparative study. J Cosmet Dermatol. 2018;17(3):495-501. https://doi.org/10.1111/jocd.12401

Maues NSF, Pires BMFB, Oliveira BGRB, Kang HC, Andrade M, Pinto JMN, Rodrigues PHC. Evolução cicatricial de feridas crônicas no uso de plasma rico em plaquetas: Série de casos. REAID. 2018;86(24):86. https://doi.org/10.31011/reaid-2018-v.86-n.24-art6

Published

2022-04-19

How to Cite

1.
Moreno DR, Domingues EA, Vallim CA, Silva RS, Fonseca JPS, Noguchi TB. PLATELET-RICH PLASMA IN VENOUS ULCER HEALING: CASE REPORT. ESTIMA [Internet]. 2022 Apr. 19 [cited 2022 May 17];20. Available from: https://www.revistaestima.com.br/estima/article/view/1158

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Section

Case report