BENEFITS OF OZONE THERAPY IN THE TREATMENT OF FOOT ULCERS IN PEOPLE WITH DIABETES MELLITUS

Authors

Abstract

Objective: To identify the benefits of ozone therapy in the treatment of foot ulcers in people with diabetes mellitus. Method: Literature review carried out in the CINAHL, Cochrane Library, LILACS, PUBMED, SciELO, SCOPUS and Web of Science databases in the period between April and May 2020. In each database, the controlled descriptors were delimited in the Science Descriptors of Health and Medical Subject Headings, keywords defined: Ozone (Ozone), Diabetic Foot (Diabetic foot), with the help of the Boolean operator AND. Results: 14 primary studies were selected. Most studies have level II evidence, published in English, in different journals, from different parts of the world. 15 benefits of ozone therapy for the treatment of foot ulcers were identified, with a predominance of increased granulation tissue and intensification in the progress of tissue repair. Conclusion: The use of ozone therapy has shown several benefits in the progress in tissue repair of foot ulcers in people with diabetes, increased granulation tissue, promoted antiseptic and bactericidal activities, preventing oxidative stress.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Caixeta HFO, Gurgel TLS, Costa MDMA, J nior JJV, Vianna ACF, Silva GR et al. Ozonioterapia no controle de infecão em cirurgia oral. ROC. 2019;3(1):37-43. https://doi.org/10.31991/v3n12019roco3

Ornelas PTSF, Sousa CM, Silva ICR, Fratelli CF. As evid ncias cient ficas da efic cia do uso da ozonioterapia frente à legislação sanitária brasileira. REVISA. 2020;9(2):320-26. https://doi.org/10.36239/revisa.v9.n2.p320a326

Projeto de Lei do Senado n. 227/2017, de 12 de julho de 2017 (BR). Autoriza a prescrição da Ozonioterapia em todo o território nacional. Bras lia (DF). 12 jul. 2017. Disponível em: https://www25.senado.leg.br/web/atividade/materias/-/materia/130041

Conselho Federal de Enfermagem, Brasília. Parecer normativo n 01/2020/DF. Brasília: Cofen; 20 de fevereiro de 2020.

Fernandes FCGM, Santos EGO, Morais JFG, Medeiros LMF, Barbosa IR. O cuidado com os pés e a prevenção da úlcera em pacientes diabéticos no Brasil. Cad Saúde Colet. 2020;28(2):302-10. https://doi.org/10.1590/1414-462X202028020258

Cardoso NA, Cisneros LL, Machado CJ, Procópio RJ, Navarro TP. Fatores de risco para mortalidade em pacientes submetidos a amputações maiores por pé diabético infectado. J Vasc Bras. 2018;17(4):296-302. https://doi.org/10.1590/1677-5449.010717

Cho NH. International Diabetes Federation. IDF Diabetes Atlas, 9 ed. International Diabetes Federation, Belgium; 2019.

Izadi M, Kheirjou R, Mohammadpour R, Aliyoldashi MH, Moghadam SJ, Khorvash F et al. Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing. Diabetes Metab Syndr. 2019;13(1):822-5. https://doi.org/10.1016/j.dsx.2018.11.060

Teuvov AA, Baziev AM, Lovpache ZN, Teunikova IS, Chudopal SM. Ozone Therapy in the Comprehensive Treatment of Diabetic Foot Syndrome. Biomed & Pharmacol J. 2017;10(4):1871-8. https://doi.org/10.13005/bpj/1306

Soares JCN, Sousa AMM, Sousa SMA, Rolim ILTP. Aleitamento materno na prevenção do câncer de mama: uma revisão integrativa da literatura. REV UNING . 2019;56(S6):13-22. Disponível em: http://revista.uninga.br/index.php/uninga/article/view/1032

Moura LR, Torres LM, Cadete MMM, Cunha CF. Factors associated with health risk behaviors among Brazilian adolescents: an integrative review. Rev Esc Enferm USP. 2018;52:e03304. https://doi.org/10.1590/S1980-220X2017020403304

Tostes MFP; Galv o CM. Implementation process of the Surgical Safety Checklist: integrative review. Rev. Latino-Am. Enfermagem. 2019;27:e3104. https://doi.org/10.1590/1518-8345.2921.3104

Ursi ES, Galvao CM. Prevenção de lesões de pele no perioperatório: revisão integrativa da literatura. Rev. Latino-Am. Enfermagem. 2006;14(1):124-31. https://doi.org/10.1590/S0104-11692006000100017

Melnyk BM, Fineout-Overholt E. Making the case for evidence-based practice. In: Melnyk BM, Fineout-Overholt E. Evidence based practice in nursing & healthcare. A guide to best practice. Philadelphia: Lippincot Williams & Wilkins; 2005. p.3-24.

Gao L, Li T, Wang S, Wang J. Comprehensive treatment of diabetic hallux gangrene with lower extremity vascular disease: A case report. J Int Med Res. 2019;47(12):6374-84. https://doi.org/10.1177/0300060519886993

Martínez AF, Martínez AF, Pérez CV, Leonard DP, López AA. Evolución de las úlceras de pie diabético con el tratamiento mixto de Heberprot-P y ozonoterapia. Rev Cubana Angiol Cir Vasc. 2019;20(1):e378. Disponível em: http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S1682 00372019000100003&lng=es&nrm=iso

Rosul MV, Patskan BM. Ozone therapy effectiveness in patients with ulcerous lesions due to diabetes mellitus. Wiad Lek. 2016;69(1):7-9. Dispon vel em: https://pubmed.ncbi.nlm.nih.gov/27162287/

Barrios JAL, Ravelo YA, D az YM, Rivero BM, Zaldivar AT. Atención multidisciplinaria con terapia avanzada y de recurso a pacientes con pie diabético en Mayabeque. Rev Cubana Angiol Cir Vasc. 2015;16(2):139-53. Dispon vel em: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1682-00372015000200003

Duarte HA, Carretero JH, Peña YA, Valcárcel JRG, Concepción, DR, Carbonell VGJ. Beneficios de la intervención con ozonoterapia en pacientes con pie diabético neuroinfeccioso. Rev Cubana Angiol Cir Vasc. 2014;15(1):12-21. Dispon vel em: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1682-00372014000100003

Zhang J, Guan M, Xie C, Luo X, Zhang Q, Xue Y. Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers. Oxid Med Cell Longev. 2014;2014:1-8. https://doi.org/10.1155/2014/273475

Fathi AM, Mawsouf MN, Viebahn-Hänsler R. Ozone Therapy in Diabetic Foot and Chronic, Nonhealing Wounds. Ozone: Science & Engineering. 2012;34(6):438-50. https://doi.org/10.1080/01919512.2012.718700

Wainstein J, Feldbrin Z, Boaz M, Harman-Boehm I. Efficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers. Diabetes Technol Ther. 2011;13(12):1255-60. https://doi.org/10.1089/dia.2011.0018

Cardoso CC, Filho ED, Pichara NL, Campos EGC, Pereira MA, Fiorini JE. Ozonoterapia como tratamento adjuvante na ferida do pé diabético. Rev méd Minas Gerais. 2010;20 (n. esp): 442-5. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/lil-568308

Monte A, Zee H, Bocci V. Major ozonated autohemotherapy in chronic limb ischemia with ulcerations. J Altern Complement Med. 2005;11(2):363-7. https://doi.org/10.1089/acm.2005.11.363

Mart nez-S nchez G, Al-Dalain SM, Men ndez S, Re L, Giuliani A, Candelario-Jalil E et al. Therapeutic efficacy of ozone in patients with diabetic foot. Eur J Pharmacol. 2005;523(1-3):151-61. https://doi.org/10.1016/j.ejphar.2005.08.020

Batista AD, Mesa MG, Manresa CP, Cepero SM. Efecto del ozono sobre la activación plaquetaria en pacientes diabéticos tratados con ozonoterapia: informe preliminar. Rev Cubana Invest Bioméd. 2001;20(1):45-7. Disponível em: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002001000100010

Oliveira MF, Viana BJF, Matozinhos FP, Silva MMS, Pinto DM, Moreira AD et al. Feridas em membros inferiores em diabéticos e não diabéticos: estudo de sobrevida. Rev Ga cha Enferm. 2019;40:e20180016. doi: https://doi.org/10.1590/1983-1447.2019.20180016

Conselho Federal de Enfermagem, Brasília. Resolução Cofen n. 567/2018. O Conselho Federal de Enfermagem − Cofen, no uso das atribuições que lhe são conferidas pela Lei n 5.905, de 12 de julho de 1973, e pelo Regimento da Autarquia, aprovado pela Resolução Cofen no. 421, de 15 de fevereiro de 2012. Brasília: Cofen; 29 de janeiro de 2018.

Published

2021-07-23

How to Cite

1.
Batista FW, Araújo T, Sousa Albuquerque Brandão MG, Aguiar Ponte V. BENEFITS OF OZONE THERAPY IN THE TREATMENT OF FOOT ULCERS IN PEOPLE WITH DIABETES MELLITUS. ESTIMA [Internet]. 2021 Jul. 23 [cited 2024 Dec. 13];19. Available from: https://www.revistaestima.com.br/estima/article/view/1090

Issue

Section

Review article