USE OF DIALKYL CARBAMOYL CHLORIDE IN THE PREVENTION AND TREATMENT OF BIOFILM IN WOUNDS

Authors

  • Paula de Souza Silva Freitas Universidade Federal do Espírito Santo − Programa de Pós-graduação em Enfermagem – Vitória (ES), Brasil.
  • Lucas Dalvi Armond Rezende Universidade Federal do Espírito Santo − Centro de Ciências da Saúde − Departamento de Enfermagem – Vitória (ES), Brasil. https://orcid.org/0000-0002-3313-852X
  • Kelly Eduarda de Jesus Silva Universidade Federal do Espírito Santo − Centro de Ciências da Saúde − Departamento de Enfermagem – Vitória (ES), Brasil. https://orcid.org/0000-0003-2539-1207
  • Bruno Henrique Fiorin Federal University of Espírito Santo (UFES)
  • Ramon Araújo dos Santos Universidade Federal do Espírito Santo − Programa de Pós-graduação em Enfermagem – Vitória (ES), Brasil. https://orcid.org/0000-0001-8239-862X
  • Aline Oliveira Ramalho Universidade de São Paulo − Escola de Enfermagem − Hospital Sírio Libanês – São Paulo (SP), Brasil. https://orcid.org/0000-0001-6065-5488

Abstract

Objectives: The aim was to identify the benefits of using Dialkyl Carbamoyl Chloride for the treatment of biofilms in wounds. Methods: This is an integrative literature review that aimed to answer the guiding question: “What are the benefits of using Dialkyl Carbamoyl Chloride in the healing of skin lesions?”. The article selection stages resulted in 13 articles included. Results: The selected articles were grouped into two groups, namely: prevention and treatment of infection in wounds and prevention of surgical site infection, with nine productions in the first group and four in the second. Studies have shown that Dialkyl Carbamoyl Chloride attenuates colonization symptoms, such as odor, pain complaints and oozing, in addition to aiding in the prophylactic management of wound biofilm. Evidence indicates that dressings with Dialkyl Carbamoyl Chloride have no adverse effects, making them viable and safe options for chronic, acute and, mainly, infected injuries. Conclusion: It was identified that Dialkyl Carbamoyl Chloride was able to promote beneficial actions in the treatment of wounds, especially those of greater complexity. The proper choice of dressings and coverings can contribute to the rational use of existing technologies and antimicrobials, culminating in cost reduction and promotion of quality of life for individuals with chronic wounds.

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References

Malone M, Bjarnsholt T, McBain AJ, James GA, Stoodley P, Leaper D et al. The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. J Wound Care. 2017;26(1):20–5. https://doi.org/10.12968/jowc.2017.26.1.20

Murphy C, Atkin L, Swanson T, Tachi M, Tan YK, Vega M et al. Consensus Document. Abordar feridas de difícil cicatrização com uma estratégia de intervenção precoce antibiofilme: higienização da ferida. J Wound Care 2020;29(Suppl3b):s1-s28. Disponível em: https://www.woundhygiene.com/media/bs3bxuod/portugal_jwc_convatec_wound-hygiene-28pp_14-feb_ca-por.pdf

Jones CM, Rothermel AT, Mackay DR. Evidence−Based Medicine: Wound Management. Plast Reconstr Surg. 2017;140(1):201e-216e. https://doi.org/10.1097/PRS.0000000000003486

Viviana SGC, Thum M, Aline OR, Beloto Silva O, Franco Coelho M, Medeiros da Silva Queiroz W et al. Analysis of “1st Brazilian Recommendation for Biofilm Management in Chronic and Complex Wounds.” ESTIMA, Braz J Enterostomal Ther. 2019;17:e1819. https://doi.org/https://doi.org/10.30886/estima.v17.783_IN

Totty JP, Hitchman LH, Cai PL, Harwood AE, Wallace T, Carradice D et al. A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride-coated dressings versus standard care for the primary prevention of surgical site infection. Int Wound J. 2019;16(4):883–90. https://doi.org/10.1111/iwj.13113

Botelho LLR, Cunha CC de A, Macedo M. O Método Da Revisão Integrativa Nos Estudos Organizacionais. Gestão e Sociedade. 2011;5(11):121−136. https://doi.org/10.21171/ges.v5i11.1220

Galvão TF, Pereira MG. Revisões sistemáticas da literatura: passos para sua elaboração. Epidemiol e Servi Saúde. 2014;23(1):183–4. http://doi.org/10.5123/S1679-49742014000100018

Pinto AM, Cerqueira MA, Bañobre-Lópes M, Pastrana LM, Sillankorva S. Bacteriophages for Chronic Wound Treatment: fromTraditional to Novel Delivery Systems. Viruses. 2020;12(2):235. https://doi.org/10.3390/v12020235

Powers JG, Higham C, Broussard K, Phillips TJ. Wound healing and treating wounds: Chronic wound care and management. J Am Acad Dermatol. 2016;74(4):607-25. https://doi.org/10.1016/j.jaad.2015.08.070

Bowler PG. Antibiotic resistance and biofilm tolerance: a combined threat in the treatment of chronic infections. J Wound Care. 2018;27(5):273–7. https://doi.org/10.12968/jowc.2018.27.5.273

Pieper B, Sobeck J, Kaljee L, Templin TN. A Descriptive Study Using an Intercept Survey: Knowledge, Attitudes, Beliefs, and Behaviors About Systemic Antibiotic Use in Adults Who Reported a Wound Within the Previous Year. J Wound Ostomy Continence Nurs. 2020;47(1):20–5. https://doi.org/10.1097/WON.0000000000000612

Meuleneire F. Infection management: The use of DACC-coated dressings in the management of wound infection. Br J Nurs. 2012;21(Sup2):4–7. https://doi.org/10.12968/bjon.2012.21.Sup2.4

Chadwick P, Ousey K. Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review. J Wound Care. 2019;28(6):370–82. https://doi.org/10.12968/jowc.2019.28.6.370

Romain B, Mielcarek M, Delhorme JB, Meyer N, Brigand C, Rohr S et al. Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study). BJS open. 2020;4(2):225–31. https://doi.org/10.1002/bjs5.50259

Boyar V. Efficacy of dialkylcarbamoylchloride-coated dressing in management of colonized or infected neonatal and pediatric wounds. J Wound Ostomy Continence Nurs. 2016;43(5):547–50. https://doi.org/10.1097/WON.0000000000000266

Biter LU, Beck GMN, Mannaerts GHH, Stok MM, Ham AC, Grotenhuis BA. The use of negative-pressure wound therapy in pilonidal sinus disease: a randomized controlled trial comparing negative-pressure wound therapy versus standard open wound care after surgical excision. Dis Colon Rectum. 2014;57(12):1406–11. https://doi.org/10.1097/DCR.0000000000000240

Bua N, Smith GE, Totty JP, Pan D, Wallace T, Carradice D et al. Dialkylcarbamoyl Chloride Dressings in the Prevention of Surgical Site Infections after Nonimplant Vascular Surgery. Ann Vasc Surg. 2017;44:387–92. https://doi.org/10.1016/j.avsg.2017.03.198

Dwiyana RF, Gondokaryono SP, Rahardja JI, Diana IA, Yogya Y, Gunawan H. Clinical efficacy of dialkylcarbamoylchloride-coated cotton acetate dressing versus combination of normal saline dressing and 2% mupirocin ointment in infected wounds of epidermolysis bullosa. Dermatol Ther. 2019;32(5):e13047. https://doi.org/10.1111/dth.13047

Denyer J. Infection management: Antimicrobial management for children with epidermolysis bullosa. Br J Nurs. 2012;21(Sup2):8–10. https://doi.org/10.12968/bjon.2012.21.Sup2.8

Bruce Z. Using Cutimed® Sorbact® hydroactive on chronic infected wounds. Wounds UK. 2012;8(1):119–29. Disponível em: https://www.researchgate.net/publication/286986985_Using_CutimedR_SorbactR_hydroactive_on_chronic_infected_wounds

Lee JW, Park SH, Suh IS, Jeong HS. A comparison between DACC with chlorhexidine acetate-soaked paraffin gauze and foam dressing for skin graft donor sites. J Wound Care. 2018;27(1):28–35. https://doi.org/10.12968/jowc.2018.27.1.28

Published

2021-07-16

How to Cite

1.
de Souza Silva Freitas P, Rezende LDA, Eduarda de Jesus Silva K, Fiorin BH, Araújo dos Santos R, Ramalho AO. USE OF DIALKYL CARBAMOYL CHLORIDE IN THE PREVENTION AND TREATMENT OF BIOFILM IN WOUNDS. ESTIMA [Internet]. 2021 Jul. 16 [cited 2021 Sep. 23];19. Available from: https://www.revistaestima.com.br/estima/article/view/1087

Issue

Section

Review article